<i>Streptococcus salivarius</i> K12 inhibits <i>Candida albicans</i> aggregation, biofilm formation and dimorphism

Candida albicans causes candidiasis, particularly in immunocompromised patients. Streptococcus salivarius K12 (K12) is a probiotic isolated from healthy oral cavity. The study aimed to determine the effect of on C. aggregation, biofilm formation and dimorphism. ATCC MYA-4901, acquired immunodeficiency syndrome (AIDS) isolate (ALC2), cancer (ALC3) were used study. All strains grown yeast peptone dextrose agar brain heart infusion agar, respectively, prior dimorphism assays. Auto-aggregation MYA-4901 ALC2 was categorised as high, while co-aggregation low presence K12. total cell count decreased significantly when co-cultured with compared monocultured (p < 0.05). Inhibition yeast-to-hyphae transition also observed In conclusion, inhibits